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Oral Muscle Relaxants for the Treatment of Chronic Pain Associated with Cerebral Palsy PMC

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Oral Muscle Relaxants for the Treatment of Chronic Pain Associated with Cerebral Palsy PMC

While they all have similar mechanisms of action (in that they directly act on the central nervous system), they have different chemical structures and indications for use. Some have stronger sedative effects than others, while others are used to treat specific medical conditions (for example, injuries or diseases of the spinal cord). Muscle relaxers are a group of drugs used to treat musculoskeletal pain, meaning pain involving muscles, bones, joints, and connective tissues like ligaments and tendons. Muscle relaxers are sometimes prescribed to people with osteoarthritis («wear-and-tear» arthritis) as well as those with lower back pain, neck pain, and other musculoskeletal pain.

Tetrahydrocannabinol (THC), the compound responsible for the inhibiting psychoactive effects of cannabis, may have muscle relaxant properties, for example. The side effects of IV dantrolene include breathing changes that occur due to weakness in the respiratory muscles and muscle weakness. The latter involves an injection of the drug into the spinal canal.The brand name of this medication is Lioresal in the U.S. The recommended dosage for people over 12 years old is 800 mg three to four times a day. However, some people require higher dosages, such as 7.5 to 10.0 mg three times a day. There is a risk of severe drowsiness or sedation if a person takes this medication and an opioid.

How are Tizanidine and Flexeril Different?

It works by blocking nerve impulses that are sent to your brain and effectively reduces spasticity by slowing down nerve signal transmission in the spinal cord. Tizanidine is used for managing spasticity due to multiple sclerosis or spinal cord injury; it does not cure these problems but allows more normal movement as the disease/condition progresses. Providers mainly prescribe antispasmodic skeletal muscle relaxants for musculoskeletal and myofascial pain, especially lower back pain, and muscle spasms. Although antispastics and antispasmodics are both types of skeletal muscle relaxants, they have specific and different uses.

What is spastic diplegia cerebral palsy? – Medical News Today

What is spastic diplegia cerebral palsy?.

Posted: Fri, 26 May 2023 07:00:00 GMT [source]

Baclofen is considered the first-line treatment for spasticity, especially for adults who have spinal cord injuries. Spasticity is a disruption in muscle movement patterns that causes certain muscles to contract all at once when you try to move or even at rest. It’s usually caused by damage to nerve pathways within your brain or spinal cord that control movement and stretch reflexes. Muscle relaxants are an important adjunct in CP therapy and are crucial in treatment of pain, as well as enabling participation in other forms of treatments. Evidence exist to support their use, however, it is not without risk and further research is required to highlight proper dosing, co-treatments and patient selection.

The generic version of Flexeril, cyclobenzaprine, is widely available. Flexeril is structurally similar to tricyclic antidepressants and primarily works in the central nervous system (CNS). It helps reduce muscle hyperactivity through actions on the gamma- and alpha-motor systems. Zanaflex is available as an oral tablet in strengths of 2 mg and 4 mg. It also comes as an oral capsule in strengths of 2 mg, 4 mg, and 6 mg.

Coverage and cost comparison of Zanaflex vs. Flexeril

CP is a permanent, chronic, non-progressive neuromuscular and neurocognitive disorder of motor dysfunction that is diagnosed in infancy and is frequently (62% of patients) accompanied by chronic or recurrent muscular pain. Treatment of pain is crucial, and focuses mostly on treatment of spasticity through non-interventional techniques, surgery and medical treatment. Botulinum toxin injections provide temporary denervation, at the cost of repeated needle sticks. More recently, the use of oral muscle relaxants has gained ground and more evidence are available to evaluate its efficacy. Common oral muscle relaxants include baclofen, dantrolene and diazepam. Baclofen is commonly prescribed for spasticity in CP; however, despite year-long experience, there is little evidence to support its use and evidence from controlled trials are mixed.

  • While OTC and natural alternatives are helpful and can be used with more potent muscle relaxants, it is essential to seek medical advice before starting or combining them.
  • Flexeril (a discontinued brand name in the U.S. that is still used to refer to the drug cyclobenzaprine) works at the brainstem, just below the brain, decreasing muscle activity by acting upon motor nerves.
  • She has an interest in medical writing and has a keen interest in evidence-based medicine.

Begin with a free call to an addiction & behavioral health treatment advisor. The We Level Up treatment center network delivers recovery programs that vary by each treatment facility. Behavioral therapies equip individuals with healthy coping mechanisms and valuable skills to manage cravings and triggers effectively. Furthermore, medication management may be integrated into a comprehensive treatment plan when appropriate. Cyclobenzaprine and Tizanidine, belonging to the muscle relaxants class, have distinct differences in several aspects. Your doctor will choose the best drug for you based on factors like your health and any other medications you’re taking.

Xanax also reacts with grapefruits, grapefruit juice, and alcohol to cause severe side effects. In comparison, Zanaflex vs. Xanax are both fast-acting and act by diminishing the sensitivity of specific receptors in the brain. Some effective alternatives include Flexeril, Soma (Carisoprodol), Baclofen, Robaxin (methocarbamol), and Valium.

Consult a doctor for assistance in determining the best course of action for you (Dickerson, L.M., 2010). Cyclobenzaprine is a centrally acting muscle relaxant that was found to be effective in reducing muscle spasms, pain and improve range of motion. It is not currently FDA approved for treatment of central muscle spasticity, including in CP. Some evidence support its efficacy and it may be as effective as diazepam. More evidence is required to weigh the risk and benefits of use in CP. We know that it is significantly useful in the treatment of muscle spasticity in the setting of central nervous system disorders such as cerebral palsy.

However, depending on the severity, you may need to take medications called skeletal muscle relaxants to treat muscle spasms that are beyond at-home treatments. Prescription muscle relaxers can be effective in treating spasticity, muscle spasms and muscle-related pain. But it’s important to weigh the possible risks of these medications, including their side effects and addiction potential.

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